CSF glucosylsphingosine is a central readout of GCase impairment across genetic and sporadic Parkinson’s disease
Jillian H. Kluss, Di Jiang, Shan V. Andrews, Ritesh Ravi, Romeo D. Maciuca, Buyankhishig Tsogtbaatar, Chau Tran, Meng Fang, Eric A. Macklin, Anastasia G. Henry, Michael A. Schwarzschild, Sarah Huntwork
This study measures CSF glucosylsphingosine (GlcSph) levels in Parkinson’s disease patients and finds elevated GlcSph in GBA1 carriers and sporadic PD, indicating central GCase pathway impairment.
bioRxiv · Jun 22, 2026 · PreprintMolecular Biology