Author
Harvard UniversityORCID 0000-0001-6019-8280Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Jillian H. Kluss, Di Jiang, Shan V. Andrews…·Sarah Huntwork
This study measures CSF glucosylsphingosine (GlcSph) levels in Parkinson’s disease patients and finds elevated GlcSph in GBA1 carriers and sporadic PD, indicating central GCase pathway impairment.
Mingjian Shi, Tommy Gunawan, Michael R. Setzer…·Joshua C. Gray
This study investigates the causal relationship between smoking and Parkinson's disease using genetic and proteomic data, identifying shared biological pathways and potential therapeutic targets.
Yongxing Gong, Armin Bayati, Tyler Joseph Alban…·Xiqun Chen
This study shows that Parkin is essential for neuronal differentiation and survival, and small molecule Parkin agonists like FB231 protect dopaminergic neurons in Parkinson's disease models.
Roshni Jaffery, Yuhang Zhao, Sarfraz Ahmed…·Xiqun Chen
This study identifies immune factor profiles in blood and CSF associated with LRRK2 mutations and Parkinson's disease, showing distinct changes in serum and CSF markers.
K. N. Rose, Musab M. Zorlu, Aline Fassini…·Stephen N. Gomperts
The paper shows that low-dose carbon monoxide reduces Parkinson's disease pathology in rodent models by activating HO-1, similar to the protective effect observed in smokers.
Ningbo Zheng, Roshni Jaffery, Ashley M. Guerrero…·Weiyi Peng
This study shows that the LRRK2 G2019S mutation impairs Th9 and Treg cell differentiation while enhancing Th2 differentiation through JAK/STAT3 signaling in T cells.