Pan-cancer analysis reveals that tumor microbiomes generate specific epitopes through transcriptional reprogramming
Jinman Fang, Yuxin Zhang, Wei Wang, Xiao Zuo, Tao Chen, Kecheng Li, Huiya Yang, Tianyang Zhu, Yuanliang Zhang, Dandan Wei, Jianfeng Zhang, Jialong Cui, Zhen Tang, Shouwu Zhang, Lirong Wang, , Yuanwei Zhang
This paper identifies microbial transcriptional reprogramming in tumors that generates tumor-specific epitopes, enhancing immunotherapy safety by enabling targeted T cell responses.
bioRxiv · Oct 22, 2025 · PreprintCancer Biology