The impact of distributional assumptions in gene-set and pathway analysis: how far can it go wrong?
Chi-Hsuan Ho, Yu‐Jyun Huang, Ying-Ju Lai, Rajarshi Mukherjee, Chuhsing Kate Hsiao
This study evaluates the impact of multivariate normality assumptions in gene-set analysis, finding that non-normality affects performance, especially in mixed tumor subtypes.
bioRxiv · Feb 1, 2021 · PreprintBioinformatics