Neuroendocrine-like/EMT dedifferentiation mediates resistance to EGFR inhibitors via the NRG1/HER3 axis
Alessandra Morselli, Chiara Miroglio, William Jayasekara Kothalawala, Idan Lahat, Donatella Romaniello, Cinzia Girone, Francesca Ambrosi, Boobash Raj Selvadurai, Suvendu Giri, Michela Sgarzi, Martina Mazzeschi, Sabrina Valente, Andrea De Giglio, Gianandrea Pasquinelli, Arianna Palladini, , Mattia Lauriola
The paper identifies NRG1/HER3 axis activation via NE-like/EMT dedifferentiation as a mechanism of EGFR inhibitor resistance in NSCLC and shows that combining EGFR inhibition with NRG1 neutralization can eradicate tumors.
bioRxiv · May 13, 2026 · PreprintCancer Biology