Mattia Lauriola

Hierarchical and context-dependent GR-MR signalling governs endogenous corticosteroid decoding in the heart

This study shows that corticosteroid responses in the heart are governed by a hierarchical GR-MR signaling mechanism and cellular context, with GR restraining MR output and influencing cardiomyocyte proliferation and fibroblast activation.

Neuroendocrine-like/EMT dedifferentiation mediates resistance to EGFR inhibitors via the NRG1/HER3 axis

The paper identifies NRG1/HER3 axis activation via NE-like/EMT dedifferentiation as a mechanism of EGFR inhibitor resistance in NSCLC and shows that combining EGFR inhibition with NRG1 neutralization can eradicate tumors.

Harnessing glucocorticoid receptor antagonization to enhance the efficacy of cardiac regenerative growth factors and cytokines

This paper shows that blocking glucocorticoid receptors enhances the effectiveness of growth factors in promoting cardiac regeneration by restoring MAPK/ERK signaling in cardiomyocytes.

Identification of first-in-class small molecule potential inhibitor of GDF15

This study identifies a small molecule inhibitor of GDF15 through in silico screening and validates its effects on cancer and normal cells.

Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21

This study develops a bispecific antibody targeting MERTK and EGFR to overcome drug resistance in lung cancer with mutations in exons 19, 20, and 21.

BMP7 promotes cardiomyocyte regeneration

This study identifies BMP7 as a key growth factor promoting cardiomyocyte proliferation in both mouse and zebrafish models, with potential therapeutic applications for heart regeneration.