Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella
Yifei Zhou, Yanqi Kang, Ying Liu, Ruichi Li, Dongliang Wang, Chong Yi, Yong Li, Yalin Zhang, Zhen Tian, Jiyuan Liu
The paper investigates whether glycogen phosphorylase (GP) can be an insecticidal target in Plutella xylostella by evaluating the effects of GP inhibitors and showing that metabolic compensation via gluconeogenesis prevents insecticidal activity.
eLife · Sep 29, 2026Peer-reviewedBiochemistry