Mechanical Signaling Regulates DNA Methylation to Maintain Muscle Stem Cell Quiescence
Pukana Jayaraman, Paige R Deltener, Justice Paintsil, Christian Oluwadamilare Abosede, Atreyi Ghatak, Sarah Abrahamson, Chris Jurgens, Damien Parrello, Susan Eliazer
This study shows that mechanical signals regulate DNA methylation in muscle stem cells to maintain quiescence by preserving Dnmt3a expression through RhoA signaling.
bioRxiv · May 17, 2026 · PreprintCell Biology