Haplotype-resolved centromeric chromatin organization from a complete diploid human genome
Yuan Xu, Hailey Loucks, Julian M. Menendez, Fedor Ryabov, Julian Lucas, Monika Čechová, Luke B Morina, Emily Xu, Danilo Dubocanin, Cy Chittenden, Mobin Asri, Ivo Violich, Christian Ortiz, Joshua M.V. Gardner, Todd L. Hillaker, , Karen H. Miga
The paper uses a complete diploid human genome to study centromeric chromatin organization, revealing that DNA methylation regulates centromere structure and plasticity.
bioRxiv · Mar 31, 2026 · PreprintGenomics