Cellular Modeling of CLN6 with IPSC-derived Neurons and Glia
María Gabriela Otero, Jaemin Kim, Yogesh K. Kushwaha, Alex C. Rajewski, Fabian David Nonis, Chintda Santiskulvong, Serguei Bannykh, Hiral Oza, Hafiz Muhammad Umer Farooqi, Madeline Babros, Christina Freeman, Lucie Dupuis, Saadat Mercimek-Andrews, Roberto Mendoza‐Londono, Catherine J. Bresee, , Tyler Mark Pierson
The paper develops CLN6 patient-derived iPSC models to study neurodegeneration, finding significant lysosomal and synaptic pathway changes in differentiated neurons.
bioRxiv · Jan 29, 2024 · PreprintNeuroscience