Dynamic single-molecule binding of carbamazepine explains diffuse cryo-EM density in the SUR1 drug-binding pocket
Christina Karafyllia, Katarzyna Walczewska-Szewc
The paper investigates the diffuse cryo-EM density of carbamazepine in the SUR1 drug-binding pocket and finds it results from dynamic single-molecule binding rather than dimerization.
bioRxiv · Jun 14, 2026 · PreprintMolecular Biology