Reduced melanocortin tone mediates increased feeding during pregnancy in mice
Ingrid Camila Possa‐Paranhos, Kerem Catalbas, Samuel Congdon, Tanya Pattnaik, Christina Nelson, Dajin Cho, Patrick R. Sweeney
This study identifies that increased AgRP neuron activity and decreased POMC neuron activity during pregnancy in mice drive hyperphagia, with spatial transcriptomics revealing transcriptional changes in these neurons.
bioRxiv · Aug 22, 2025 · PreprintNeuroscience