A bivalent Lassa virus mRNA vaccine protects guinea pigs from lethal infection with Lassa virus
Mei Hashizume, Takeshi Saito, Ryotaro Nouda, Takashi Matsuzaki, Shintaro Yamada, Gavriella Siman-Tov, Daiki Kobayashi, Christine Click, Kirsten E. Littlefield, Emily Schugardt, Igor S. Lukashevich, Juan Carlos de la Torre, Junki Maruyama, Masaharu Iwasaki
This study evaluates a bivalent Lassa virus mRNA vaccine in mice and guinea pigs, showing it provides complete protection against lethal infection, whereas monovalent vaccines do not.
bioRxiv · Oct 27, 2026 · PreprintMicrobiology