CD39 defines a cytotoxic tumor-associated NK cell state responsive to NKG2A blockade in lung cancer
Clara Serger, Lucas Rebuffet, Michael T. Sandholzer, Wiebke Rackwitz, Irene Fusi, Petra Herzig, Annalea Brüggemann, Carina A. Pawlow, Evgeny Chichelnitskiy, Daniel Hajnal, Nicole Oelgarth, Sarp Uzun, Christoph Schultheiß, Andreas Zingg, Sofia Tundo, , Alfred Zippelius
The paper identifies CD39+ tumor-associated NK cells as a cytotoxic effector state in NSCLC responsive to NKG2A blockade through multiomic analysis.
bioRxiv · Aug 26, 2025 · PreprintImmunology