Convergent network effects along the axis of gene expression during prostate cancer progression
Konstantina Charmpi, Tiannan Guo, Qing Zhong, Ulrich Wagner, Rui Sun, Nora C. Toussaint, Christine Fritz, Chunhui Yuan, Hao Chen, Niels J. Rupp, Ailsa J. Christiansen, Dorothea Rutishauser, Jan H. Rüschoff, Christian Daniel Fankhauser, Karim Saba, , Andreas Beyer
The paper investigates how genomic alterations affect molecular networks in prostate cancer by integrating genomic, transcriptomic, and proteomic data from 105 samples, identifying a sub-network predictive of tumor aggressiveness and recurrence.
Genome biology · Dec 14, 2020Peer-reviewedSystems Biology