Konstantina Charmpi

Proteostasis dysregulation in p.A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson's disease model with Lewy-like pathology

This study shows that p.A53T-α-Synuclein astrocytes from Parkinson's patients impair proteostasis, leading to neurodegeneration and Lewy-like pathology in co-cultured neurons.

Optimizing Network Propagation for Multi-Omics Data Integration

This paper compares network propagation algorithms for multi-omics data integration and identifies optimal parameter settings for different research questions.

Deciphering the Signaling Network Landscape of Breast Cancer Improves Drug Sensitivity Prediction

The paper uses single-cell proteomics and perturbation experiments to improve drug sensitivity predictions in breast cancer and identify genomic features associated with treatment response.

Convergent network effects along the axis of gene expression during prostate cancer progression

The paper investigates how genomic alterations affect molecular networks in prostate cancer by integrating genomic, transcriptomic, and proteomic data from 105 samples, identifying a sub-network predictive of tumor aggressiveness and recurrence.

Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

This study quantifies spatial proteome heterogeneity in prostate tissues using multi-region analysis and identifies biomarker variability across benign and malignant tissues.