A Weight Loss Fibrotic Response in Visceral Fat Is Driven by Defective Lysosome-Dependent Collagenolysis
Clémentine Rebière, Amanda Oliveira, Sébastien Dussaud, Iman Haddad, Agatha de Assis-Ferreira, Adma Maciel Babêtto, Christine Rouault, Fatiha Merabtene, Cheïma Benbida, Jimon Boniface Abatan, Simone Vargas da Silva, Laís Bhering Martins, Lícia Torres, Ana Letícia Malheiros Silveira, Cindy Rose, , Geneviève Marcelin
This study shows that weight loss fails to reverse visceral fat fibrosis due to impaired collagen degradation, suggesting ECM clearance enhancement as a therapeutic target.
bioRxiv · Oct 5, 2026 · PreprintPathology