The positive inside rule is stronger when followed by a transmembrane helix.
Minttu T Virkki, Christoph Peters, Daniel Nilsson, Therese Sörensen, Susana Cristobal, Björn Wallner, Arne Elofsson
The study shows that the positive inside rule enhances translocon recognition of marginally hydrophobic transmembrane helices when followed by a transmembrane helix, but is not sufficient alone.
Journal of Molecular Biology · Aug 1, 2014Peer-reviewedMolecular Biology