Integrative analysis of 5-methyl- and 5-hydroxymethylcytosine indicates a role for 5-hydroxymethylcytosine as a repressive epigenetic mark
Christopher E. Schlosberg, John R. Edwards
The paper introduces ME-Class2, a machine-learning tool for analyzing 5mC, 5hmC, and gene expression, revealing 5hmC's role in gene repression and activation based on methylation dynamics.
bioRxiv · May 10, 2018 · PreprintBioinformatics