John R. Edwards

The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.

This study shows that HER2 and TP53 co-mutant cancers have increased histone acetylation and are sensitive to neratinib plus trastuzumab deruxtecan.

This study shows that DNMT3A mutations in TBRS disrupt cortical interneuron differentiation, leading to neuronal network dysfunction and contributing to intellectual disability and autism.

The paper identifies a mitofusin 2 mutation (R400Q) that causes mitophagic cardiomyopathy by impairing mitochondrial fusion and Parkin recruitment, distinct from its role in CMT2A.

DXM deconvolves methylation profiles of subpopulations from heterogeneous bisulfite sequencing data, showing improved performance over existing methods and linking methylation to relapse in DLBCLs.

This study shows that pericentromeric hypomethylation in zebrafish triggers an interferon response, linking it to ICF syndrome-like phenotypes.

The paper introduces ME-Class2, a machine-learning tool for analyzing 5mC, 5hmC, and gene expression, revealing 5hmC's role in gene repression and activation based on methylation dynamics.