Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression
Bolun Li, Thong Luong, Elelta Sisay, Jinhu Yin, Zixuan Zhang, Maryam Vaziripour, Ju Hye Shin, Yongmei Zhao, Bao Tran, Jinyoung Byun, Yafang Li, Chia Han Lee, Maura O'Neill, Þorkell Andrésson, Yoon Soo Chang, , Jiyeon Choi
The paper presents an isoform-level lung cell atlas using single-cell long-read RNA-sequencing, revealing genetic effects on isoform regulation that improve cell-type classification and identify novel variants associated with lung cancer risk.
bioRxiv · Mar 30, 2026 · PreprintGenetics