Erping Long

Scaling genetic discovery through automated post-GWAS interpretation

This paper introduces PGI, a system that automates post-GWAS interpretation, achieving high recovery of findings and enabling cross-study biological evidence accumulation.

Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression

The paper presents an isoform-level lung cell atlas using single-cell long-read RNA-sequencing, revealing genetic effects on isoform regulation that improve cell-type classification and identify novel variants associated with lung cancer risk.

Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology

The paper constructs a single-cell eQTL dataset from Asian never-smokers, identifying alveolar cell-specific genes linked to lung cancer susceptibility.

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as modulating risk for melanoma and nevi via RAS activation

This study identifies RAPGEF1 as a gene modulating melanoma and nevi risk through RAS activation, using fine-mapping, expression data, and functional assays.

Genetic determinants of gene expression noise and its role in complex trait variation

The paper identifies genetic determinants of gene expression noise and links them to complex trait variation using a large-scale human blood cell dataset.

Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis-regulation

The paper identifies candidate causal variants and genes at melanoma risk loci using capture-HiC and integrates multi-omics data to prioritize cis-regulatory interactions.

Context-aware single-cell multiome approach identified cell-type specific lung cancer susceptibility genes

The paper identifies cell-type specific lung cancer susceptibility genes by integrating single-cell multi-omics data with GWAS loci.

Dynamic response to initial stage blindness in visual system development

The study investigates retinal development in infants with initial stage blindness, showing environmental influences on retinal malleability and its potential role in visual system plasticity.