Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease Modeling.
Qian‐Quan Sun, Yihan Wang, Chunzhao Zhang
The paper constructs a human-specific prefrontal circuit model using transcriptomic data, revealing divergent oscillatory dynamics and highlighting the need for human-specific recalibration of conductance parameters.
bioRxiv · Aug 3, 2026 · PreprintNeuroscience