Machine-learning-guided enzyme discovery and redox-system engineering for efficient production of the nylon monomer methyl 12-aminododecanoate in Escherichia coli
Myco Umemura, Yasushi Kamisaka, Masaki Yamamoto, Yuki Kuriya, Naoki Watanabe, Chuya Tateishi, Takuya Hashimoto, Manabu Kanno, Shuhei Noda, Michihiro Araki, Kazuhiro Fujimori, Junya Ikuta
This study uses machine learning to discover enzymes for producing ADAME in E. coli, achieving a 5.6-fold improvement over existing methods.
bioRxiv · Sep 11, 2026 · PreprintBioengineering