Addressing confounding artifacts in reconstruction of gene co-expression networks
Princy Parsana, Claire Ruberman, Andrew E. Jaffe, Michael C. Schatz, Alexis J. Battle, Jeffrey T. Leek
This study shows that removing top principal components from gene expression data improves gene co-expression network reconstruction by reducing false discoveries, using GTEx data and simulated examples.
Genome biology · May 16, 2019Peer-reviewedGenomics