IS-capades of Klebsiella pneumoniae: Insertion sequences drive metabolic loss in obscure sub-lineages
Ben Vezina, Claire White, Helena B. Cooper, Kathryn E. Holt, Jane Hawkey, Kelly L. Wyres, Margaret M. C. Lam
The paper investigates the relationship between insertion sequences (IS) and metabolic capacity in four Klebsiella pneumoniae sub-lineages, finding higher IS loads correlate with reduced metabolic gene numbers and substrate utilisation.
bioRxiv · Jul 24, 2025 · PreprintGenomics