Margaret M. C. Lam

The paper develops a rules-based classifier to predict ciprofloxacin resistance in Klebsiella pneumoniae from genotype data and demonstrates its global distribution association with quinolone consumption.

The paper proposes the Life Identification Number (LIN) system as a stable, multilevel strain taxonomy for bacterial pathogens based on core genome MLST to improve epidemiological tracking and nomenclature consistency.

This study characterizes the diversity and niche associations of plasmids in Klebsiella pneumoniae species complex isolates from human, animal, and marine sources, revealing distinct patterns of antimicrobial resistance and virulence gene distribution.

This study investigates whether the rmpADC operon alone can increase virulence in classical Klebsiella pneumoniae strains, finding that HMV is necessary but not sufficient for hypervirulence.

This study identifies simple sequence repeats in rmpA and rmpD/rmpC genes that mediate phase variation of the mucoid phenotype in hypervirulent Klebsiella pneumoniae, enabling adaptation to different infection niches.

The paper benchmarks 44 tools for plasmidome reconstruction from short-read assemblies in Klebsiella pneumoniae, finding PlaScope and MOB-suite as top performers.

The paper investigates the relationship between insertion sequences (IS) and metabolic capacity in four Klebsiella pneumoniae sub-lineages, finding higher IS loads correlate with reduced metabolic gene numbers and substrate utilisation.

This study analyzes KpSC populations across human, animal, and marine sources in Norway, showing distinct yet overlapping populations with limited recent transmission between niches.

This paper reclassifies SHV β-lactamase alleles in K. pneumoniae genomes based on mutations, improving genotype-phenotype understanding and updating the Kleborate tool.

The paper analyzes the genetic diversity and functionality of rmpADC variants in Klebsiella pneumoniae to understand their role in virulence and antimicrobial resistance.

This study evaluates ONT-only assemblies for genomic surveillance of Klebsiella pneumoniae, showing reliable MLST, K type, and AMR detection but challenges in cluster detection.

Kaptive 2.0 updates capsule and LPS locus typing for Klebsiella pneumoniae by adding novel sequences and improving O2 antigen prediction, enabling better surveillance and control strategies.

The paper introduces Kleborate, a tool for analyzing K. pneumoniae genomes, demonstrating its use in genomic surveillance and metagenomic analysis of gut samples.

The paper investigates t(m)DNAs as integration sites for genomic islands and prophages in Klebsiella pneumoniae, finding their role in horizontal gene transfer and genome evolution.

The paper identifies two Klebsiella pneumoniae isolates with convergent virulence and multidrug resistance genes on a single plasmid, highlighting the risk of rapid emergence of hypervirulent multidrug-resistant strains.

This study identifies and tracks virulence loci encoding siderophore synthesis in K. pneumoniae using genomic surveillance tools.

This study identifies yersiniabactin, colibactin, and an expanded resistome as factors contributing to the enhanced virulence and persistence of KPC-2-producing K. pneumoniae CG258 in South America.

This study analyzes the population genomics of hypervirulent Klebsiella pneumoniae clonal group 23, revealing its early emergence and global spread through genomic analysis of 98 isolates.