Prion infection, transmission and cytopathology modelled in a low-biohazard human cell line
Merve Avar, Daniel Heinzer, Nicolas Steinke, Berre Doğançay, Rita Moos, Séverine Lugan, Claudia Cosenza, Simone Hornemann, Olivier Andréoletti, Adriano Aguzzi
The paper describes a human cell line, hovS, that can be infected with sheep-derived prions and exhibits prion-related cytopathology, offering a safer alternative to human prion studies.
Life Science Alliance · Jun 30, 2020Peer-reviewedNeuroscience