Robust Myocardial Regeneration After Selective Cardiomyocyte Loss Is Driven by Cardiac Stem Cell Activation Through the miR-221-p57 Axis
Eleonora Cianflone, Fabiola Marino, Mariangela Scalise, Andrew J. Smith, Chiara Siracusa, L Pagano, Claudia Quercia, Nadia Salerno, Assunta Di Costanzo, Giovanni Canino, A D A Antonella De Angelis, Georgina M. Ellison, Konrad Urbanek, Bernardo Nadal‐Ginard, Daniele Torella
This study shows that selective cardiomyocyte loss in mice triggers cardiac stem cell activation via the miR-221-p57 axis, leading to complete myocardial regeneration.
bioRxiv · Jul 13, 2026 · PreprintCell Biology