Alpha-2-Macroglobulin/LRP1 signaling promotes mitochondrial clearance and autophagic extracellular vesicle release in erythroid cells
Julieta Jacob, SR Castro Pérez, Betiana Nebaí Salassa, Cécile Deleschaux, Agustín F Campos Londero, Alice Dussouchaud, Sophie Denise Lefevre, Gustavo Alberto Chiabrando, Mariano A. Ostuni, Claudio Marcelo Fader
This study shows that 2M* activates mitophagy and promotes EV release via LRP1 in erythroid cells, linking autophagy and vesicular trafficking.
bioRxiv · Jun 13, 2026 · PreprintMolecular Biology