LM-GVP: A Generalizable Deep Learning Framework for Protein Property Prediction from Sequence and Structure
Zichen Wang, Steven A. Combs, Ryan M. Brand, Miguel Romero Calvo, Panpan Xu, George Price, Nataliya Golovach, Emmanuel Oluwatobi Salawu, Colby J. Wise, Sri Priya Ponnapalli, Peter Clark
This study introduces LM-GVP, a deep learning framework combining a protein Language Model and Graph Neural Network to predict protein properties from sequence and structure, outperforming existing methods on fluorescence, protease stability, and Gene Ontology function prediction.
bioRxiv · Sep 21, 2021 · PreprintSynthetic Biology