RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection
Vikas Peddu, Alexander Hill, Sreelakshmi Velandi Maroli, Connor Mattingly, Joshua M.V. Gardner, Karen H. Miga, Rebecca Claire Fitzgerald, Daniel H. Kim
This study uses long-read nanopore sequencing of cell-free RNA to detect early-stage cancer and discover novel biomarkers, identifying 270,679 intergenic RNAs and potential therapeutic targets.
bioRxiv · Jul 2, 2025 · PreprintGenomics