Vikas Peddu

RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection

This study uses long-read nanopore sequencing of cell-free RNA to detect early-stage cancer and discover novel biomarkers, identifying 270,679 intergenic RNAs and potential therapeutic targets.

Transposable element RNA dysregulation in mutant KRAS(G12C) 3D lung cancer spheroids

This study investigates how KRAS(G12C) mutations affect transposable element RNA expression in 3D lung cancer spheroids, finding mutation-specific TE RNA dysregulation and activation of Alu-derived RNAs with innate immunity genes.

Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expression in vivo that correlates with increased antibody immune response.

This study identifies tissue-specific RNA expression of integrated HHV-6A/B in vivo and links it to increased antibody responses against specific viral antigens.

Consensus Machine Learning for Gene Target Selection in Pediatric AML Risk

The paper uses a consensus machine learning approach to identify gene targets associated with pediatric AML risk, finding recurrently selected genes like HOXA9 and MEIS1 across multiple algorithms.

RNA sequencing of the in vivo human herpesvirus 6B transcriptome to identify targets for clinical assays distinguishing between latent and active infections

This study uses RNA sequencing to analyze HHV-6B transcriptomes in various samples to identify diagnostic targets distinguishing latent from active infections.