The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels
Matthew R. McFarland, Corina D Keller, Brandon M. Childers, Stephen A. Adeniyi, Holly Corrigall, Adélaïde Raguin, Maria Carmen Romano, Ian Stansfield
The paper investigates how depletion of the glutamine tRNA synthetase (Gln4p) in yeast triggers a GCN4 amino acid starvation response despite maintaining charged tRNA levels.
Nucleic Acids Research · Jan 18, 2020Peer-reviewedSystems Biology