Self-supervised AI reveals a lethal discohesive phenotype in lung adenocarcinoma
Kai Rakovic, Alexandrina Pancheva, Adalberto Claudio Quiros, Jose Coelho‐Lima, Zhangyi He, David A. Dorward, Marco Sereno, Claire Wilson, Craig Dick, David Allan Moore, Fiona Ballantyne, Catherine Ficken, Ana Teodòsio, Silvia Martinelli, Rachel Baird, , John P. C. Le Quesne
This paper uses self-supervised AI to identify under-appreciated stromal morphologies in lung adenocarcinoma linked to poor prognosis, independent of current clinical schemas.
bioRxiv · Nov 12, 2025 · PreprintCancer Biology