Mechanistic Modeling of Periodontal Pathogen Fusobacterium nucleatum-Induced Epithelial Oncogenic Transformation in Carcinomas via Selected FadA-Lactate-Angiogenesis Pathway
T. Christopher Windham, Cris Mantilla, Jimena García
This study models how Fusobacterium nucleatum induces epithelial oncogenic transformation through the FadA-lactate-angiogenesis pathway, identifying lactate accumulation and VEGF upregulation as key factors in cancer progression.
bioRxiv · Mar 10, 2025 · PreprintCancer Biology