Depletion of BBSome Subunits Alters Receptor Endocytosis and Promotes EMT via TGF-β Signaling
Carlos Solarat, J. Barra-Carneiro, S. Vila-Almuíña, Cristian Alvela, Pablo Barbeito, Margarita Soloshenko, Maria Schrøder Holm, Noor Gammoh, Søren T. Christensen, Diana Valverde
This study shows that BBS1 and BBS4 deficiencies disrupt receptor endocytosis and alter TGF-β signaling, leading to EMT and affecting autophagy in retinal epithelial cells.
bioRxiv · Oct 23, 2024 · PreprintMolecular Biology