Author

Crystal A. Ruff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

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Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Paul‐Michael AgapowiD· 1 shared Rory Popert· 1 shared Sharad AgarwaliD· 1 shared Shikta Gupta· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperNeuroscience

Paul‐Michael AgapowORCID

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1 paper

Recent·Most cited

From APOE Genetics to AI-Designed Drug Candidates: An Integrated Pipeline for Oral, Brain-Penetrant ACAT1 Inhibitors in Alzheimer's Disease

Sharad Agarwal, Rory Popert, Paul‐Michael Agapow, Crystal A. Ruff, Shikta Gupta

This paper presents an AI-driven drug discovery platform for designing oral, brain-penetrant ACAT1 inhibitors for Alzheimer's disease, identifying promising lead candidates with favorable properties.

bioRxiv · May 26, 2026 · PreprintNeuroscience