Inducible formation of leading cells driven by CD44 switching gives rise to collective invasion
Cuixia Yang, Manlin Cao, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Feng Gao
The paper shows CD44hi leading cells drive collective invasion in luminal breast cancer through reversible CD44 switching, highlighting plasticity in cancer cell states.
bioRxiv · Aug 7, 2018 · PreprintCancer Biology