Base composition at the start of the coding sequence controls the balance between translation initiation and mRNA degradation in E. coli .
Anna Lipońska, Laura Monlezun, Isaac Wilkins, Saravuth Ngo, Thomas Oïffer, Cylia Bouchachi, John Francis Hunt, Daniel P. Aalberts, Grégory Boël
The paper shows that A-rich first six codons in E. coli mRNAs enhance translation initiation and stability, leading to higher protein expression.
Nucleic Acids Research · Oct 29, 2025Peer-reviewedMicrobiology