Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling
Shah Wajed, Yann Ferrandez, Mahel Zeghouf, Rasta Ghasemi, Cylia Puertas, Agata Nawrotek, Franck Gesbert
The paper investigates the RhoG G12E mutant, showing impaired GTP hydrolysis and altered cellular phenotypes despite GTP accumulation, highlighting the importance of nucleotide cycling in RhoG signaling.
bioRxiv · Apr 1, 2026Biochemistry