Poisson poisoning as the mechanism of action of the microtubule-targeting agent colchicine
M. Hemmat, M. Braman, D. Escalante, D. J. Odde
This study identifies colchicine's mechanism as Poisson poisoning of microtubule ends, revealing it acts as a true kinetic stabilizer through low-affinity binding and time-dependent effects.
bioRxiv · Mar 25, 2020 · PreprintBiophysics