M. Hemmat

Poisson poisoning as the mechanism of action of the microtubule-targeting agent colchicine

This study identifies colchicine's mechanism as Poisson poisoning of microtubule ends, revealing it acts as a true kinetic stabilizer through low-affinity binding and time-dependent effects.

Atomistic basis of microtubule dynamic instability assessed via multiscale modeling

The paper uses multiscale modeling to show that GTP hydrolysis in microtubules causes bond weakening and bending, driving dynamic instability and tip structures observed in microscopy.

Multi-scale Computational Modeling of Tubulin-Tubulin Lateral Interaction

This study uses multi-scale modeling to show that lateral tubulin interactions are not the main driver of microtubule dynamic instability, linking atomistic simulations to cellular behavior.