Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy
D. ZHU, D. H. Brookes, A. Busia, A. Carneiro, C. Fannjiang, G. Popova, D. Shin, E. F. Chang, T. J. Nowakowski, J. Listgarten, D. V. Schaffer
This paper develops a machine learning method to design more effective AAV libraries with better packaging capabilities and diversity, achieving higher success rates in gene therapy applications.
bioRxiv · Nov 2, 2021Bioengineering