Hyperextended telomeres promote C-circle formation in telomerase positive human cells
C. Y. Jones, C. L. Williams, S. P. Moreno, D. K. Morris, C. Mondello, J. Karlseder, A. A. Bertuch
This study shows that hyperextended telomeres in telomerase-positive cells promote C-circle formation, independent of telomerase activity and replication stress, suggesting C-circles are not exclusive to ALT.
bioRxiv · Jan 26, 2023Cancer Biology