Fibrous caps in atherosclerosis form by Notch-dependent mechanisms common to arterial media development
C. J. Martos Rodriguez, J. Albarran-Juarez, D. Morales Cano, A. Caballero, D. MacGrogan, J. L. de la Pompa, L. Carramolino, J. F. Bentzon
This study shows Notch signaling in smooth muscle cells is critical for fibrous cap formation in atherosclerosis, with loss or gain of Notch affecting SMC contribution to plaques.
bioRxiv · Sep 28, 2020Pathology