B cells engineered to express an anti-HIV antibody allow memory retention, class switch recombination and clonal selection in mice
A. D. Nahmad, Y. Raviv, M. Horovitz-Fried, I. Sofer, T. Akriv, D. Nataf, I. Dotan, D. Burstein, Y. Wine, I. Benhar, A. Barzel
This study shows engineered B cells expressing anti-HIV antibodies can persist in mice, undergo class switch recombination, and show clonal selection after immunization.
bioRxiv · Feb 28, 2020Immunology