Variability of the innate immune response is globally constrained by transcriptional bursting
N. Alachkar, D. Norton, Z. Wolkensdorfer, M. Muldoon, P. Paszek
The paper analyzes TLR-induced gene expression variability using single-cell data and stochastic models, showing that gene response heterogeneity is captured by mean-variance relationships.
bioRxiv · Feb 20, 2023Immunology