Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model
S. Patra, C.-W. Lin, M. K. Ghosh, S. M. Havens, S. A. Cory, D. H. Russell, D. P. Barondeau
The paper engineers a bacterial cysteine desulfurase to recapitulate the frataxin activation mechanism, supporting the architectural switch model by showing FXN compensates for lost subunit interactions.
bioRxiv · Oct 6, 2020 · PreprintBiochemistry