D. R. Grimes

Is biomedical research self-correcting? Modelling insights on the persistence of spurious science

This paper models the self-correction dynamics in biomedical research, showing that research waste and corrective effort depend on false positive rates and time delays in correcting spurious findings.

Hypoxia increases the tempo of evolution in glioblastoma

This study shows hypoxia accelerates tumour evolution by increasing cell division and mutation rates in glioblastoma.

Oxygen diffusion in ellipsoidal tumor spheroids

This paper derives equations for oxygen diffusion in ellipsoidal tumor spheroids and quantifies the limits of assuming perfect sphericity, leading to improved methods for measuring oxygen consumption rates.

Modeling Science Trustworthiness Under Publish Or Perish Pressure

This paper models how publish-or-perish pressures affect scientific trustworthiness, finding that funding and false positive rates significantly impact reproducibility.